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The Information Systems Security Line of Business (ISS LoB) initiative was launched in 2005 by the OMB. Its goal is to improve the level of information systems security across government agencies and reduce costs by sharing common processes and functions for managing information systems security. Several agencies have been designated as service providers for computer security awareness training and FISMA reporting.

The ISS LoB identifies common information security needs across the Federal Government and delivers product and service solutions to improve information security program performance, reduce costs, and increase efficiency across the federal enterprise.

ISS LoB is currently addressing four common information systems security needs across the government:

The ISS LoB delivers these solutions through the establishment of government Shared Service Centers (SSCs) and also partners with the General Services Administration (GSA) to deliver strategic government-wide acquisition vehicles.